The Eastern Mediterranean has long suffered from a complex security setting, which is made up of both traditional security challenges as well as asymmetric threats. More recently, we started to witness the additional effect of a couple of new challenges, which have set in motion a rebalancing of powers in the region and may threaten its stability even further: the Arab Spring and the recent offshore energy findings. These developments can affect US and European interests in multiple ways and, therefore, the EU, in coordination with Washington, should take on a pivotal role in addressing them. Dr. Skordeli previously held the role of Senior Political Advisor to the former Prime Minister of Greece, Kostas Karamanlis.