HIV and AIDS have dealt a devastating blow to Africa—socially, economically, politically, spiritually, and on all sectors of African society. The core of indigenous structures and systems—that is, the community and the sacredness of life—has seen an upheaval. Women of all ages have borne the heaviest brunt of this blow as evidenced in the following: the myth that female virginity can provide a cure; women being more vulnerable and having a higher infection rate; sex and sexuality related choices such as the use of condoms; to breastfeed or not; widow guardianship versus wife inheritance; women as the chief care givers; the grandmother turned parent; women being the more vulnerable with regard to stigma and discrimination. On the other hand, HIV and AIDS have seen women at various levels take a leading and leadership role through community social support groups, and being directors and key players in networks engaged in advocacy and resource mobilization.